Mechanisms of oxidative stress and vascular dysfunction.

نویسندگان

  • Z S Nedeljkovic
  • N Gokce
  • J Loscalzo
چکیده

The endothelium regulates vascular homoeostasis through local elaboration of mediators that modulate vascular tone, platelet adhesion, inflammation, fibrinolysis, and vascular growth. Impaired vascular function contributes to the pathogenesis of atherosclerosis and acute coronary syndromes. There is growing pathophysiological evidence that increased generation of reactive oxygen species and oxidative stress participates in proatherogenic mechanisms of vascular dysfunction and atherothrombosis. In this review, the role of oxidative stress in mechanisms of vascular dysfunction is discussed, and potential antioxidant strategies are reviewed.

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عنوان ژورنال:
  • Postgraduate medical journal

دوره 79 930  شماره 

صفحات  -

تاریخ انتشار 2003